PHARMADEV Pharmacochimie et Biologie pour le Développement

Publications PEPS



  • Girardi C., Vasquez-Ocmin P., Castillo D., Sauvain M., Rojas R., Fabre N., Haddad M. Biological activities of 13,28-epoxyoleanane triterpene saponins from two Peruvian Myrsinaceae. Revista Sociedad Quimica Peru. 78, 2012
  • Haddad M, Le Lamer A. C., Moreno y Banuls L., Carraz M, Vasquez P., Vaisberg A., Castillo D., Sauvain M, Rojas R., Kiss R. (2012). In vitro growth inhibitory effects of 13, 28-epoxyoleanane triterpene saponins in cancer cells. Planta Medica, 78 (11), 1184-1185.
  • Vansteelandt M, Kerzaon I, Blanchet E, Tankoua OF, Du Pont TR, Joubert Y, Monteau F, Le Bizec B, Frisvad JC, Pouchus YF, Grovel O. (2012). Patulin and secondary metabolite production by marine-derived Penicillium strains. FUNGAL BIOLOGY, 116 (9), 954-961.
  • Rojas R., Ruiz C., Gonzalez G., Bourdy G., Doroteo V.H., Alban J., Castillo D., Robert G., Deharo E. Role of Mitraphylline in the anti-inflammatory properties of Uncaria tomentosa bark used in Amazonian traditional medicine. J. Ethnopharmacol. 2012, 143, 801-804.
  • Rojas-Duran R., Gonzalez-Aspajo G., Ruiz-Martel C., Bourdy G, Doroteo-Ortega V. H., Alban-Castillo J., Robert G., Auberger P., Deharo E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143 (3), 801-804.
  • Houël, E., Stien, D., Bourdy G., Deharo, E. (2012) Quassinoids: anticancer and antimalarial activities. In Handbook of Natural Products. Springer Ed.
  • Le H. L., Jullian VBourdy G, Girardi C., Deharo E, Le Lamer A. C., Fabre N. (2012). Sensitivity enhancement in LC-ESI-MS method using mobile phase additives to quantify Simalikalactone E. Planta Medica, 78 (11), 1198-1198.
  • Rossi F., Jullian V., Pawlowiez R., Kumar-Roiné S., Haddad M., Darius HT., Gaertner-Mazouni N, Chinain M., Laurent D. (2012) Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin. Journal of Ethnopharmacology 143 : 33-40. Roué M., Quévrain E., Domart-Coulon, I., Bourguet-Kondracki M.L. (2012). Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products. Natural product reports., 2012, 29, 739-751
  • Ruiz S.B., Rojas Duran R., Sauvain M., Caldas J., Kalinowski J, Falcón Perez N., Shiva Ramayoni C. (2012) Evaluación del aceite essencial de Orégano (Oreganum vulgare) y extracto deshidrato de Jengibre (Zingiber officinale) como potenciales promotores de crecimiento en polos de engorde. Revista de investigaciones veterinarias del Peru – RIVEP (Lima), 23: 160-170.
  • Rivaud M., Mendoza A., Sauvain MValentin A., Jullian V. (2012). Short synthesis and antimalarial activity of fagaronine. Bioorganic and Medicinal Chemistry, 20 (15), 4856-4861.
  • Robert G., Jullian V, Jacquel A., Ginet C., Dufies M., Torino S., Pottier A., Peyrade F., Tartare-Deckert S., Bourdy GDeharo E, Auberger P. (2012). Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway. Oncotarget, 3 (12), 1688-1699.
  • Fabre N., Deharo E, Le H. L., Girardi C., Valentin A., Jullian V. (2012). LC-ESI-MS/MS analysis of Quassia amara leaves tea. Is antiplasmodial activity of the tea is due to quassinoids?. Planta Medica, 78 (11), 1262-1262.
  • Bertani S., Houel E., Jullian VBourdy GValentin A., Stien D., Deharo E. (2012). New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae). Experimental Parasitology, 130 (4), 341-347.
  • El Babili F., Fouraste I., Rougaignon C., Moulis C., Chatelain C. (2012). Anatomical study of secondary tuberized roots of Harpagophytum procumbens DC and quantification of harpagoside by high-performance liquid chromatography method. Pharmacognosy Magazine, 8 (30), 175-180.
  • Bourdy G., Jullian V., Deharo E., Auberger P., Robert, G. Utilisation de la Simalikalactone E comme agent anticancéreux. Fr. Demande2012,  FR 2970415 A1 2012 PCT Int. Appl. 2012, WO 2012095820 A1 20120719.
  • Cabanillas B. J., Le Lamer A. C., Castillo D., Arevalo J., Estevez Y., Rojas R., Valadeau C., Bourdy GSauvain MFabre N. (2012). Dihydrochalcones and benzoic acid derivatives from Piper dennisii. Planta Medica, 78 (9), 914-918.
  • Cachet N., Ho-A-Kwie F., Rivaud M., Houëll E., Deharo EBourdy GJullian V. (2012). Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae). Phytochemistry Letters, 5 (1), 162-164.
  • Matsui M., Adib-Conquy M., Coste A., Kumar-Roine S., Pipy B., Laurent , Pauillac S. (2012). Aqueous extract of Vitex trifolia L. (Labiatae) inhibits LPS-dependent regulation of inflammatory mediators in RAW 264.7 macrophages through inhibition of Nuclear Factor kappa B translocation and expression. Journal of Ethnopharmacology, 143 (1), 24-32.
  • Mani L., Jullian V, Mourkazel B., Valentin A., Dubois J., Cresteil T., Folcher Eric, Hooper J. N. A., Erpenbeck D., Aalbersberg W., Debitus Cécile.  (2012). New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888. Chemistry and Biodiversity, 9 (8), 1436-1451.


  • Geiger M, Guitton Y, Vansteelandt M, Kerzaon I, Blanchet E, du Pont TR, Frisvad JC, Hess P, Pouchus YF, Grovel O. (2013). Cytotoxicity and mycotoxin production of shellfish-derived Penicillium spp., a risk for shellfish consumers. Letters In Applied Microbiology, 57 (5), 385-392.
  • Le Lamer AC., Ibrahim N., Manjary F., Mallet-Ladeira S., Girardi C., Valentin A., Fabre N, Moulis C. (2013). Macrocyclic spermidine alkaloids from Androya decaryi L. Perrier. Molecules, 18 (4), 3962-3971.
  • Vansteelandt M, Blanchet E, Egorov M, Petit F, Toupet L, Bondon A, Monteau F, Le Bizec B, Thomas OP, Pouchus YF, Le Bot R, Grovel O. (2013). Ligerin, an Antiproliferative Chlorinated Sesquiterpenoid from a Marine-Derived Penicillium Strain. JOURNAL OF NATURAL PRODUCTS, 76 (2), 297-301.
  • Carroux A, Van Bohemen AI, Roullier C, du Pont TR, Vansteelandt M, Bondon A, Zalouk-Vergnoux A, Pouchus YF, Ruiz N. (2013). Unprecedented 17-Residue Peptaibiotics Produced by Marine-Derived Trichoderma atroviride. CHEMISTRY & BIODIVERSITY, 10 (5), 772-786.
  • Odonne Guillaume, Valadeau C., Alban-Castillo J., Stien D., Sauvain MBourdy G. (2013). Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon). Journal of Ethnopharmacology, 146 (1), 127-153.
  • Rojas Durn R., Shiva Ramayoni C., Kalinowski Echegaray J., Villavicencio Gallarday C., Sauvain M. Composition of Lemon Peel essential Oil as a growth promoter in the poultry industry. WO/2013/129949.
  • Haddad M, Lelamer Anne-Cécile, Banuls L. M. Y., Vasquez P., Carraz M, Vaisberg A., Castillo D., Sauvain M, Rojas R., Kiss R. (2013). In vitro growth inhibitory effects of 13,28-epoxyoleanane triterpene saponins in cancer cells. Phytochemistry Letters, 6 (1), 128-134.
  • Hernandez P., Rojas R., Gilman R. H., Sauvain M, Lima L. M., Barreiro E. J., Gonzalez M., Cerecetto H. (2013). Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates. European Journal of Medicinal Chemistry, 59, 64-74.
  • Houël E., Stien D., Bourdy G., Deharo E. (2013) Chapter 161: Quassinoids: anticancer and antimalarial activities. In Ramawat, Kishan Gopal; Merillon, Jean-Michel (Eds.), Handbook of Natural Products, Springer, ISBN 978-3-642-22143-9.”
  • Egorov M.,* Le Bot R.,* Petit F.,* Grovel O.,* Pouchus Y. F.,* Vansteelandt M.,* Preparation of fumagillol derivatives useful for the treatment or prevention of bone tumors. Brevet français (dépôt le 28/03/2011) FR 2973376 B1, 2013* : contribution équivalente des auteurs notés dans l’ordre alphabétique et selon chaque organisme (Atlanthera/Université de Nantes)