Publications BIOCID

  • Borovsky, D., Hancock, R.G., Rougé, P., Powell, C.A., Shatters, R.G. Juvenile hormone affects the splicing of Culex quinquefasciatus early trypsin messenger. (2018). RNA. Arch. Insect Biochem. Physiol. 99, e21506.
  • Cano L, Cerapio JP, Ruiz E, Marchio A, Turlin B, Casavilca S, Taxa L, Marti G, Deharo E, Pineau P, Bertani S. Liver clear cell foci and viral infection are associated with non- cirrhotic, non-fibrolamellar hepatocellular carcinoma in young patients from South America. (2018) Rep. 8(1):9945.
  • Chassagne F, Haddad M, Amiel A, Phakeovilay C, Manithip C, Bourdy G, Deharo E, Marti M. A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. (2018). Fitoterapia 127:226-36.
  • Fauquert, J.-L., Michaud, E., Pereira, B., Bernard, L., Gourdon-Dubois, N., Rouzaire, P.- O., Rochette, E., Merlin, E., Evrard, B., PITA Group. Peanut gastrointestinal delivery oral immunotherapy in adolescents: Results of the build-up phase of a randomized, double- blind, placebo-controlled trial (PITA study). (2018). Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. 48, 862–874.
  • Fersing C, Boudot C, Pedron J, Hutter S, Primas N, Castera-Ducros C, Bourgeade-Delmas S, Sournia-Saquet A, Moreau A, Cohen A, Stigliani JL, Pratviel G, Crozet MD, Wyllie S, Fairlamb A, Valentin A, Rathelot P, Azas N, Courtioux B, Verhaeghe P, Vanelle P. 8-Aryl-6- chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases. Eur J Med Chem. 157:115-126.
  • Fodé D, Vial T, Ferraris P, Wichit S, Bengue M, Hamel R, Talignani L, Liegeois F, Pompon J, Yssel H, Marti G, Missé D. Zika virus infection modulates the metabolomic profile of microglial cells. (2018). PLOS ONE. 13(10): e0206093.
  • Machicado C, Bertani S, Herrera-Velit P, Espinoza J, Ruiz E, Marcos L. Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: a preliminary report. (2018). Soc. Bras Med. Trop. 51(2):231-233.
  • Haidara M, Haddad M, Denou A, Marti M, Bourgeade-Delmas S, Sanogo R, Bourdy G, Aubouy A. In vivo validation of anti-malarial activity of crude extracts of Terminalia Macroptera, a Malian medicinal plant. (2018). Malaria J. 17(1).
  • Marchio A, Cerapio JP, Ruiz E, Cano L, Casavilca S, Terris B, Deharo E, Dejean A, Bertani S, Pineau P. Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden. (2018) Rep. 8(1):12031.
  • Paboriboune P, Vial T, Chassagne F, Sitbounlang P, Soundala S, Bertani S, Sengmanothong D, Babin FX, Steenkeste N, Dény P, Pineau P, Deharo E. A seven-year retrospective study on the surveillance of hepatitis B in Laos. (2018). J. Hepatol. 2018:9462475..
  • Pedron J, Boudot C, Bourgeade-Delmas S, Sournia-Saquet A, Paloque L, Rastegari M, Abdoulaye M, El-Kashef H, Bonduelle C, Pratviel G, Wyllie S, Fairlamb AH, Courtioux B, Verhaeghe P, Valentin A. Antitrypanosomatid Pharmacomodulation at Position 3 of the 8- Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions. 2018. 13(20):2217-2228.
  • Pedron J, Boudot C, Hutter S, Bourgeade-Delmas S, Stigliani JL, Sournia-Saquet A, Moreau A, Boutet-Robinet E, Paloque L, Mothes E, Laget M, Vendier L, Pratviel G, Wyllie S, Fairlamb A, Azas N, Courtioux B, Valentin A, Verhaeghe P. Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. Eur J Med Chem. 2018 Jul 15;155:135-152.
  • Paboriboune P, Vial T, Sitbounlang P, Bertani S, Trépo C, Dény P, Babin FX, Steenkeste N, Pineau P, Deharo E. Hepatitis C in Laos: a 7-year retrospective study on 1765 patients. (2018). Sin. 33(4):295-303.
  • Pineau P, Ruiz E, Deharo E, Bertani S. On hepatocellular carcinoma in South America and early-age onset of the disease. (2018). Clin. Res. Hepatol. Gastroenterol. pii: S2210- 7401(18)30235-3.
  • Poiroux, G., Barre, A., Rouge, P., Benoist, H., Targeting Glycosylation Aberrations To Improve The Efficiency Of Cancer Phototherapy. (2018). Curr. Cancer Drug Targets. DOI : 10.2174/1568009618666180628101059.
  • Quiliano M, Pabón A, Moles E, Bonilla-Ramirez L, Fabing I, Fong KY, Nieto-Aco DA, Wright DW, Pizarro JC, Vettorazzi A, López de Cerain A, Deharo E, Fernández-Busquets X, Garavito G, Aldana I, Galiano S. Structure-activity relationship of new antimalarial 1-aryl- 3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery. (2018). J. Med. Chem. 152:489-514.
  • Ramadani AP, Paloque L, Belda, Tamhid HA, Masriani, Jumina, Augereau JM, Valentin A, Wijayanti MA, , Mustofa, Benoit-Vical F. Antiprotozoal properties of Indonesian medicinal plant extracts. J Herb Med 11:46-52.
  • Rodríguez YV, Arias MH, García JO, Deharo E, Garavito G. Pharmacological activity of Curarea toxicofera in combination with classical antimalarial treatments. (2018). Ethnopharmacol. 222:288-294.
  • Villaret J, Marti G, Dubois F, Reybier K, Gaudre N, Haddad M, Valentin A. Adaptation of a microbead assay for the easy evaluation of traditional anti-sickling medicines: application to DREPANOSTAT and FACA. Pharm Biol. 56(1):385-392.
  • Zhang C, Bourgeade Delmas S, Fernández Álvarez Á, Valentin A, Hemmert C, Gornitzka H. Synthesis, characterization, and antileishmanial activity of neutral N-heterocyclic carbenes gold(I) complexes. Eur J Med Chem. 2018. 143:1635-1643.

  • Arias M. H., Deharo E, Valentin A., Garavito G. (2017). Adaptation and optimization of a fluorescence-based assay for in vivo antimalarial drug screening. Parasitology Research, 116 (7), 1955-1962.
  • Azando E. V. B., Olounlade A. P., Hounzangbe-Adote M. S., Ha T. B. T., Fabre N., Valentin A. (2017). Control of gastro-intestinal parasites with essential oil from Zanthoxylum zanthoxyloides (Fagara zanthoxyloides). Revue De Medecine Veterinaire, 168 (10-12), 205-212.
  • Barre A., Delplanque A., Simplicien M., Benoist H., Rouge P. (2017). Molecular basis of cross-reactivity between Act c 12 and other seed 11S-globulin allergens. Revue Francaise D Allergologie, 57 (2), 58-66.
  • Barre A., Delplanque A., Simplicien M., Benoist H., Rouge P. (2017). Is maize a safe food for patients with celiac disease?. Revue Francaise D Allergologie, 57 (5), 375-381.
  • Ben Mahmoud S., Ramos J. E., Shatters R. G., Hall D. G., Lapointe S. L., Niedz R. P., Rouge P., Cave R. D., Borovsky D. (2017). Expression of Bacillus thuringiensis cytolytic toxin (Cyt2Ca1) in citrus roots to control Diaprepes abbreviatus larvae. Pesticide Biochemistry and Physiology, 136, 1-11.
  • Cassagnes L. E., Rakotoarivelo N., Sirigu S., Perio P, Najahi E., Chavas L. M. G., Thompson A., Gayon R., Ferry G., Boutin J. A., Valentin A., Reybier K., Nepveu F. (2017). Role of quinone reductase 2 in the antimalarial properties of indolone-type derivatives. Molecules, 22 (2).
  • Chassagne F., Deharo E, Punley H., Bourdy G. (2017). Treatment and management of liver diseases by Khmer traditional healers practicing in Phnom Penh area, Cambodia. Journal of Ethnopharmacology, 202, 38-53.
  • Chervin J., Perio P, Martins-Froment N., Pharkeovilay C., Reybier K., Nepveu F., Fabre N., Talou T., Bonzon-Ponnet V., Marti G. (2017). Dereplication of natural products from complex extracts by regression analysis and molecular networking: case study of redox-active compounds from Viola alba subsp. dehnhardtii. Metabolomics, 13 (8).
  • Dang L. Y., Rouge P., Van Damme E. J. M. (2017). Amaranthin-Like Proteins with Aerolysin Domains in Plants. Frontiers in Plant Science, 8.
  • Dang L. Y., Rouge P., Van Damme E. J. M. (2017). Expression Analysis of Ribosome-inactivating Proteins From Cucumber. Progress in Biochemistry and Biophysics, 44 (10), 929-941.
  • De Schutter K., Tsaneva M., Kulkarni S. R., Rouge P., Vandepoele K., Van Damme E. J. M. (2017). Evolutionary relationships and expression analysis of EUL domain proteins in rice (Oryza sativa). Rice, 10.
  • Poiroux G., Barre A., van Damme E. J. M., Benoist H., Rouge P. (2017). Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Prognosis and Therapy. International Journal of Molecular Sciences, 18 (6).
  • Quiliano M., Pabon A., Ramirez-Calderon G., Barea C., Deharo E, Galiano S., Aldana I. (2017). New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: in silico ADMET, antiplasmodial and antileishmanial activity. Bioorganic and Medicinal Chemistry Letters, 27 (8), 1820-1825.
  • Rouge P., Barre A. (2017). New sweeteners: Potential food allergens. Revue Francaise D Allergologie, 57 (3), 203-205.
  • Sanchez-Carranza J. N., Alvarez L., Marquina-Bahena S., Salas-Vidal E., Cuevas V., Jiminez E. W., Veloz R. A., Carraz M, Gonzalez-Maya L. (2017). Phenolic compounds isolated from Caesalpinia coriaria induce S and G2/M phase cell cycle arrest differentially and trigger cell death by interfering with microtubule dynamics in cancer cell lines. Molecules, 22 (4).
  • Van Holle S., Rouge P., Van Damme E. J. M. (2017). Evolution and structural diversification of Nictaba-like lectin genes in food crops with a focus on soybean (Glycine max). Annals of Botany, 119 (5), 901-914.
  • Wytynck P., Rouge P., Van Damme E. J. M. (2017). Genome-wide screening of Oryza sativa ssp japonica and indica reveals a complex family of proteins with ribosome-inactivating protein domains. Phytochemistry, 143, 87-97.

  • Barre A, Bienevenu F, Velasquez E, Delplanque A, Caze-Subra S, Garnier L, Viel S, Bienvenu J, Benoist H, Rougé P. Les allergènes croisants des insectes comestibles. Rev. Fr. Allergol. 2016,56:522-532.
  • Barre A, Bienvenu F, Caze-Subra S, Degaud M, Viel S, Garnier L, Bienvenu J, Rougé P. L'association Alt a 1 (Alternaria) – Act d 2 (kiwi) : origine et pertinence clinique possible. Rev. Fr. Allergol. 2016,56:84-89.
  • Barre A, Delplanque A, Simplicien M, Benoist H, Rougé P. Bases moléculaires de la réactivité croisée entre Act c 12 et les allergènes globulines 11S des graines: identification in silico des épitopes B d’Act c Rev. Fr. Alllergol. 2016
  • Barre A., Bienvenu F., Caze-Subra S., Degaud M., Viel S., Garnier L., Bienvenu J., Rouge P. (2016). The association of Alta 1 (Alternaria) with Act d 2 (kiwi): Origin and potential clinical relevance. Revue Francaise D Allergologie, 56 (2), 84-89.
  • Ben Mahmoud S, Ramos J, Shatters R, Hall D, Lapointe S, Niedze R, Rougé P, Cave R, Borovsky D. Expression of Bacillus thuringiensis cytolytic toxin (Cyt2Ca1) in Citrus roots to control Diaprepes abbreviatus larvae. Pestic. Biochem. Physiol. 2016
  • Cadelis M. M., Bourguet-Kondracki M. L., Dubois J., Valentin A., Barker D., Copp B. R. (2016). Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorganic & Medicinal Chemistry, 24 (14), 3102-3107.
  • Chassagne F, Bourdy G, Deharo E, Sovanmoly H : Natural remedies used by Bunong people in Mondulkiri province, Northeast Cambodia. (2016). J Ethnopharmacol Sep;191:41-70.
  • Chassagne F., Hul S., Deharo E, Bourdy G. (2016). Natural remedies used by Bunong people in Mondulkiri province (Northeast Cambodia) with special reference to the treatment of 11 most common ailments. Journal of Ethnopharmacology, 191, 41-70.
  • Chassagne F., Rojas T. R., Bertani S, Bourdy G, Eav S., Ruiz E., Pineau P., Deharo E. (2016). A 13-year retrospective study on primary liver cancer in Cambodia: a strikingly high hepatitis C occurrence among hepatocellular carcinoma cases. Oncology, 91 (2), 106-116.
  • Chervin J., Marti G., Perio P, Martins N., Reybier K., Nepveu F., Fabre N., Vilarem G., Talou T. (2016). LC-MS based metabolomic approach applied to bioactive molecules identification: case study of a comprehesive chemodiversity screening of Viola genus. Planta Medica, 82 (S 01).
  • Culerrier R., Carraz M., Mann C., Djabali M. (2016). MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence. Molecular Biology of the Cell, 27 (17), 2726-2734.
  • Hayes M, Rougé P, Barre A, Herouet-Guicheuey L, Roggen EL . In silico tools for exploring potential human allergy to proteins. Drug Discov. Today Dis. Models 2016
  • Houel E., Nardella F., Jullian V, Valentin A., Vonthron-Senecheau C., Villa P., Obrecht A., Kaiser M., Bourreau E., Odonne G., Fleury Marie, Bourdy G, Eparvier V., Deharo E, Stien D. (2016). Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians. Journal of Ethnopharmacology, 187, 241-248.
  • Mollinedo P., Vila J. L., Arando H., Sauvain M, Deharo E, Bravo J. A. (2016). Anti-infective assessment of Senecio smithioides (Asteraceae) and isolation of 9-oxoeuryopsin, a furanoeremophilane-type sesquiterpene with antiplasmodial activity. Natural Product Research, 30 (22), 2594-2597.
  • Quiliano M, Mendoza A, Fong KY, Pabon A, Goldfarb NE, Fabing I, Vettorazzi A, Lopez de Cerain A, Dunn BM, Garavito G, Wright DW, Deharo E, Pérez-Silanes S, Aldana I, Galiano S. Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration. Int J Parasitol Drugs Drug Resist. (2016) 6(3):184-198.
  • Quiliano M., Mendoza A., Fong K. Y., Pabon A., Goldfarb N. E., Fabing I., Vettorazzi A., de Cerain A. L., Dunn B. M., Garavito G., Wright D. W., Deharo E, Perez-Silanes S., Aldana I., Galiano S. (2016). Exploring the scope of new arylamino alcohol derivatives: synthesis, antimalarial evaluation, toxicological studies, and target exploration. International Journal for Parasitology-Drugs and Drug Resistance, 6 (3), 184-198.
  • Rakotoarivelo N., Ibrahim N., Ibrahim H., Cabou C., Vivas L., Thompson E., Nallet J.P., Nepveu F., Valentin A. Antimalarial activity of 2-Aryl-3H-indol-3-one formulated in albumin-based nanosuspensions. Jacobs J Med. Chem. 2016, 2(1) : 006.
  • Rougé P, Barre A. Les thaumatin-like protéines. Rev. Fr. Allergol. 2016,56:262-263.
  • Rouge P., Barre A. (2016). Thaumatin-like proteins. Revue Francaise D Allergologie, 56 (3), 262-263.
  • Ruiz E, Rojas Rojas T, Berropsi F, Chavez I, Luque C, Cano L, Doimi F, Pineau P, Deharo E, Bertani S. Hepatocellular carcinoma surgery outcomes in the developing world: a 20-year retrospective cohort study at the National Cancer Institute of Peru. (2016). Heliyon. 2(1):e
  • Shang C. J., Rouge P., Van Damme E. J. M. (2016). Ribosome Inactivating Proteins from Rosaceae. Molecules, 21 (8).
  • Wang J. Y., Pearce A. N., Chan S. T. S., Taylor R. B., Page M. J., Valentin A., Bourguet-Kondracki M. L., Dalton J. P., Wiles S., Copp B. R. (2016). Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-beta-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum. Journal of Natural Products, 79 (3), 607-610.

  • Azebaze A. G. B., Teinkela J. E. M., Nguemfo E. L., Valentin A., Dongmo A. B., Vardamides J. C. (2015). Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia. African Health Sciences, 15 (3), 835-840.
  • Barre A., Caze-Subra S., Gironde C., Bienvenu F., Bienvenu J., Rouge P. (2015). What about the allergenicity of sweet-tasting proteins? Revue Francaise D Allergologie, 55 (5), 363-371.
  • Ben-Mahmoud S., Ramos J. E., Shatters R. G., Rouge P., Powell C. A., Smagghe G., Borovsky D. (2015). Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L. (Coleoptera: Curculionidae). Journal of Insect Physiology, 72, 1-13.
  • Boselli L., Carraz M, Mazeres S., Paloque L., Gonzalez G., Benoit-Vical F., Valentin A., Hemmert C., Gornitzka H. (2015). Synthesis, structures, and biological studies of heterobimetallic Au(I)-Ru(II) complexes involving N-heterocyclic carbene-based multidentate ligands. Organometallics, 34 (6), 1046-1055.
  • Carraz M, Lavergne C., Jullian V, Wright M., Gairin J. E., de la Cruz M. G., Bourdy G. (2015). Antiproliferative activity and phenotypic modification induced by selected Peruvian medicinal plants on human hepatocellular carcinoma Hep3B cells. Journal of Ethnopharmacology, 166, 185-199.
  • Chabir N., Ibrahim H., Romdhane M., Valentin A., Moukarzel B., Mars M., Bouajila J. (2015). Seeds of Peganum Harmala L. Chemical Analysis, Antimalarial and Antioxidant Activities, and Cytotoxicity Against Human Breast Cancer Cells. Medicinal Chemistry, 11 (1), 94-101.
  • Chawech R., Jarraya R., Girardi C., Vansteelandt M., Marti G., Nasri I., Racaud-Sultan C., Fabre N. (2015). Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad. Molecules, 20 (10), 18001-18015.
  • Cohen A., Suzanne P., Lancelot J. C., Verhaeghe P., Lesnard A., Basmaciyan L., Hutter S., Laget M., Dumetre A., Paloque L., Deharo E, Crozet M. D., Rathelot P., Dallemagne P., Lorthiois A., Sibley C. H., Vanelle P., Valentin A., Mazier D., Rault S., Azas N. (2015). Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium. European Journal of Medicinal Chemistry, 95, 16-28.
  • El Souda SS, Matloub AA, Nepveu F, Valentin A, Roques C. Phenolic composition and prospective anti-infectious properties of Atriplex lindleyi. (2015). Asian Pac. J. Trop. Dis., 5(10):930-935.
  • Erb M, Robert CAM, Marti G, Lu J, Doyen GR, Villard N, Barriere Y, French BW, Wolfender JL, Turlings TCJ, Gershenzon J. (2015). A Physiological and Behavioral Mechanism for Leaf Herbivore-Induced Systemic Root Resistance. PLANT PHYSIOLOGY, 169 (4), 2884-2894.
  • Gonzalez-Aspajo G., Belkhelfa H., Haddioui-Hbabi L., Bourdy G, Deharo E. (2015). Sacha Inchi Oil (Plukenetia volubilis L.), effect on adherence of Staphylococus aureus to human skin explant and keratinocytes in vitro. Journal of Ethnopharmacology, 171, 330-334.
  • Gutjahr C, Sawers RJH, Marti G, Andres-Hernandez L, Yang SY, Casieri L, Angliker H, Oakeley EJ, Wolfender JL, Abreu-Goodger C, Paszkowski U. (2015). Transcriptome diversity among rice root types during asymbiosis and interaction with arbuscular mycorrhizal fungi. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112 (21), 6754-6759.
  • Harper J. L., Khalil I. M., Shaw L., Bourguet-Kondracki M. L., Dubois J., Valentin A., Barker D., Copp B. R. (2015). Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B. Marine Drugs, 13 (8), 5102-5110.
  • Houel E., Fleury Marie, Odonne G., Nardella F., Bourdy G, Vonthron-Senecheau C., Villa P., Obrecht A., Eparvier V., Deharo E, Stien D. (2015). Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaime (Psidium acutangulum Mart. ex DC., Myrtaceae). Journal of Ethnopharmacology, 166, 279-285. ISSN 0378-8741
  • Houël E., Gonzalez G., Bessière J. M., Odonne G., Eparvier V., Deharo E, Stien D. (2015). Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products. Memorias do Instituto Oswaldo Cruz, 110 (1), 106-113.
  • Ibrahim N., Ibrahim H., Sabater A. M., Mazier D., Valentin A., Nepveu F. (2015). Artemisinin nanoformulation suitable for intravenous injection: preparation, characterization and antimalarial activities. International Journal of Pharmaceutics, 495 (2), 671-679.
  • Kieffer C., Cohen A., Verhaeghe P., Paloque L., Hutter S., Castera-Ducros C., Laget M., Rault S., Valentin A., Rathelot P., Azas N., Vanelle P. (2015). Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series. Bioorganic & Medicinal Chemistry, 23 (10), 2377-2386.
  • Le H. L., Jullian V, Claparols C., Vansteelandt M., Haddad M, Cabou C., Deharo E, Fabre N. (2015). Development and validation of liquid chromatography combined with tandem mass spectrometry methods for the quantitation of simalikalactone E in extracts of Quassia amara L. and in mouse blood. Phytochemical Analysis, 26 (2), 111-118.
  • Mollinedo P., Vila J.L., Arando ACL Sauvain M., Deharo E, Bravo J.A. 9-Oxoeuryopsin, antimalarial furanoeremophilane-type sesquiterpene from Senecio smithioides (Asteraceae). (2015). Nat. Prod. Res. 25: 1-4.
  • Paloque L., Hemmert C., Valentin A., Gornitzka H. (2015). Synthesis, characterization, and antileishmanial activities of gold(I) complexes involving quinoline functionalized N-heterocyclic carbenes. European Journal of Medicinal Chemistry, 94, 22-29.
  • Queiroz MMF, Marti G, Queiroz EF, Marcourt L, Castro-Gamboa I, Bolzani VS, Wolfender JL. (2015). LC-MS/MS Quantitative Determination of Tetrapterys mucronata Alkaloids, a Plant Occasionally used in Ayahuasca Preparation. PHYTOCHEMICAL ANALYSIS, 26 (3), 183-188.
  • Segui, B ; Andrieu-Abadie, N ; Levade, T ; Colacios V, Céline; Rochaix, P ; Bertrand, F; Benoist, H; Rochotte, J. New method for treating melanoma. N° WO/2015/173259, Demande internationale: PCT/EP2015/060512. Date de dépot international: 12/5/2015 ; date de publication : 19/11/2015. Déposants : INSERM, CHU Toulouse, CCR Toulouse, UPS. Auteurs :
  • Van Ekert E., Shatters R. G., Rouge P., Powell C. A., Smagghe G., Borovsky D. (2015). Cloning and expressing a highly functional and substrate specific farnesoic acid o-methyltransferase from the Asian citrus psyllid (Diaphorina citri Kuwayama). Febs Open Bio, 5, 264-275.
  • Virard F., Cousty S., Cambus J. P., Valentin A., Kemoun P., Clement F. (2015). Cold Atmospheric Plasma Induces a Predominantly Necrotic Cell Death via the Microenvironment. Plos One, 10 (8).
  • Wang J, Pearce AN, Chan ST, Taylor RB, Page MJ, Valentin A, Bourguet-KondrackiML, Dalton JP, Wiles S, Copp BR. Biologically Active Acetylenic Amino Alcohol and N- Hydroxylated 1,2,3,4-Tetrahydro-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum. J Nat Prod. 2015 Dec
  • Wolfender J. L., Marti G., Thomas A., Bertrand S. (2015). Current approaches and challenges for the metabolite profiling of complex natural extracts. Journal of Chromatography A, 1382, 136-164.

  • Barre A., Caze-Subra S., Gironde C., Bienvenu F., Bienvenu J., Rouge P. (2014). Entomophagy and the risk of allergy. Revue Francaise D Allergologie, 54 (4), 315-321.
  • Berry A, Mone H, Iriart X, Mouahid G, Aboo O, Boissier J, Fillaux J, Cassaing S, Debuisson C, Valentin A, Mitta G, Theron A, Magnaval JF. (2014). Schistosomiasis Haematobium, Corsica, France. EMERGING INFECTIOUS DISEASES, 20 (9), 1595-1597.
  • Boselli L., Ader I., Carraz M, Hemmert C., Cuvillier O., Gornitzka H. (2014). Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands. European Journal of Medicinal Chemistry, 85, 87-94.
  • Deharo E, Jullian V, Bertani S., Bourdy G. (2014). La simalikalactone E, molécule antipaludique et anticancer = Simalikalactone E, anti-malarial and anticancer molecule. Biofutur, (350), 56-59.
  • Gil A., Pabon A., Galiano S., Burguete A., Perez-Silanes S., Deharo E, Monge A., Aldana I. (2014). Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents. Molecules, 19 (2), 2166-2180.
  • Houel E., Fleury M., Jullian V, Vonthron-Senecheau C., Nardella F., Villa P., Odonne G., Eparvier V., Deharo E, Stien D. (2014). Takamalalme (Psidium acutangulum Mart ex. DC) : understanding the use of an antimalarial traditional remedy from French Guiana. Planta Medica, 80 (10), 797-797.
  • Houel E., Rodrigues A. M. S., Jahn-Oyac A., Bessière J. M., Eparvier V., Deharo E, Stien D. (2014). In vitro antidermatophytic activity of Otacanthus azureus (Linden) Ronse essential oil alone and in combination with azoles. Journal of Applied Microbiology, 116 (2), 288-294.
  • Lavergne R. A., Iriart X., Martin-Blondel G., Chauvin P., Menard S., Fillaux J., Cassaing S., Roques-Malecaze C., Arnaud S., Valentin A., Magnaval J. F., Marchou B., Berry A. (2014). Contribution of molecular diagnosis to the management of cutaneous leishmaniasis in travellers. Clinical Microbiology and Infection, 20 (8), O528-O
  • Marchio A., Bertani S., Rojas T. R., Doimi F., Terris B., Deharo E, Dejean A., Ruiz E., Pineau P. (2014). A peculiar mutation spectrum emerging from young Peruvian patients with hepatocellular carcinoma. Plos One, 9 (12).
  • Najahi E., Rakotoarivelo N. V., Valentin A., Nepveu F. (2014). Amino derivatives of indolone-N-oxide: Preparation and antiplasmodial properties. European Journal of Medicinal Chemistry, 76, 369-375.
  • Najahi E., Valentin A., Fabre P. L., Reybier K., Nepveu F. (2014). 2-Aryl-3H-indol-3-ones: Synthesis, electrochemical behaviour and antiplasmodial activities. European Journal of Medicinal Chemistry, 78, 269-274.
  • Nepveu F., Najahi E., Valentin A. (2014). Antimalarial Activities of Indolones and Derivatives. Current Topics in Medicinal Chemistry, 14 (14), 1643-1652.
  • Picard M, Cassaing S, Letocart P, Verdeil X, Protin C, Chauvin P, Iriart X, Cavalie L, Valentin A, Marchou B, Ruiz J, Riu-Poulenc B, Huguet F, Recher C. (2014). Concomitant cases of disseminated Geotrichum clavatum infections in patients with acute myeloid leukemia. LEUKEMIA & LYMPHOMA, 55 (5), 1186-1188.
  • Privat-Maldonado A., Soto M., Saldarriaga M.C., Alonso C., Barral A., Pacheco R., Deharo E, Montoya Y., Arevalo J. Diagnosis of American Cutaneous Leishmaniasis with Immunodominant linear epitopes. J. Immunol. 2014,
  • Van Ekert E., Heylen K., Rouge P., Powell C. A., Shatters R. G., Smagghe G., Borovsky D. (2014). Aedes aegypti juvenile hormone acid methyl transferase, the ultimate enzyme in the biosynthetic pathway of juvenile hormone III, exhibits substrate control. Journal of Insect Physiology, 64, 62-73.


  • Afoulous S., Ferhout H., Raoelison E. G., Valentin A., Moukarzel B., Couderc F., Bouajila J. (2013). Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei. Food and Chemical Toxicology, 56, 352-362.
  • Barea C., Pabon A., Perez-Silanes S., Galiano S., Gonzalez G., Monge A., Deharo E, Aldana I. (2013). New amide derivatives of quinoxaline 1,4-di-N-Oxide with leishmanicidal and antiplasmodial activities. Molecules, 18 (4), 4718-4727.
  • Bengochea P., Christiaens O., Amor F., Vinuela E., Rouge P., Medina P., Smagghe G. (2013). Insect growth regulators as potential insecticides to control olive fruit fly (Bactrocera oleae Rossi): insect toxicity bioassays and molecular docking approach. Pest Management Science, 69 (1), 27-34
  • Bertani S, Pineau P., Loli S., Moura Julien, Zimic M., Deharo E, Ruiz E. (2013). An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations. Plos One, 8 (6), e ISSN 1932-6203
  • Bienvenu F., Barre A., Viel S., Garnier L., Guyon C., Favre-Metz C., Pauli G., Bienvenu J., Rouge R. (2013). Are defensins important plant allergens? Revue Francaise D Allergologie, 53 (7), 585-590.
  • Cardeau-Desangles I, Fabre A, Cointault O, Guitard J, Esposito L, Iriart X, Berry A, Valentin A, Cassaing S, Kamar N. (2013). Disseminated Ochroconis gallopava infection in a heart transplant patient. TRANSPLANT INFECTIOUS DISEASE, 15 (3), E115-E
  • Chaker A., Najahi E., Chatriant O., Valentin A., Téné N., Treilhou M., Chabchoub F., Nepveu F. New 3-substituted-2,1-benzisoxazoles: Synthesis and antimicrobial activities,ÂArab.J. Chem., 2013
  • Festa C., De Marino S., D’Auria M. V., Taglialatela-Scafati O., Deharo E, Petek Sylvain, Zampella A. (2013). New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands. Tetrahedron, 69 (18), 3706-3713.
  • Houël E., Rodrigues A.M.S., Jahn-Oyac A., Bessière J.M., Eparvier V., Deharo E, Stien D. In vitro antidermatophytic activity of Otacanthus azureus (Linden) Ronse essential oil alone and in combination with azoles. J. Appl. Microbiol. 2013, 1-7.
  • Houël E., Stien D., Bourdy G., Deharo E. (2013) Chapter 161: Quassinoids: anticancer and antimalarial activities. In Ramawat, Kishan Gopal; Merillon, Jean-Michel (Eds.), Handbook of Natural Products, Springer, ISBN 978-3-642-22143-9. »
  • Khlifi D., Hayouni E., Valentin A., Cazaux S., Moukarzel B., Hamdi M., Bouajila J. (2013). LC-MS analysis, anticancer, antioxidant and antimalarial activities of Cynodon dactylon L. extracts. Industrial Crops and Products, 45, 240-247.
  • Lavergne R. A., Chauvin P., Valentin A., Fillaux J., Roques-Malecaze C., Arnaud S., Menard S., Magnaval J. F., Berry A., Cassaing S., Iriart X. (2013). An extraction method of positive blood cultures for direct identification of Candida species by Vitek MS matrix-assisted laser desorption ionization time of flight mass spectrometry. Medical Mycology, 51 (6), 652-656.
  • Lefevre L., Lugo-Villarino G., Meunier E., Valentin A., Olagnier D., Authier H., Duval C., Dardenne C., Bernad J., Lemesre Jean-Loup, Auwerx J., Neyrolles O., Pipy B., Coste A. (2013). The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity, 38 (5), 1038-1049.
  • Mengelle C., Mansuy J. M., Prere M. F., Grouteau E., Claudet I., Kamar N., Huynh A., Plat G., Benard M., Marty N., Valentin A., Berry A., Izopet J. (2013). Simultaneous detection of gastrointestinal pathogens with a multiplex Luminex-based molecular assay in stool samples from diarrhoeic patients. Clinical Microbiology and Infection, 19 (10), E458-E
  • Najahi E., Valentin A., Tene N., Treilhou M., Nepveu F. (2013). Synthesis and biological evaluation of new bis-indolone-N-oxides. Bioorganic Chemistry, 48, 16-21.
  • Nemni A., Borges J. P., Rouge P., Barre A., Just J. (2013). Barley’s lipid transfer protein: a new emerging allergen in pediatric anaphylaxis. Pediatric Allergy and Immunology, 24 (4), 410-411.
  • Zotti M. J., De Geyter E., Swevers L., Braz A. S. K., Scott L. P. B., Rouge P., Coll J., Grutzmacher A. D., Lenardao E. J., Smagghe G. (2013). A cell-based reporter assay for screening for EcR agonist/antagonist activity of natural ecdysteroids in Lepidoptera (Bm5) and Diptera (S2) cell cultures, followed by modeling of ecdysteroid-EcR interactions and normal mode analysis. Pesticide Biochemistry and Physiology, 107 (3), 309-320.

  • Amor F., Christiaens O., Bengochea P., Medina P., Rouge P., Vinuela E., Smagghe G. (2012). Selectivity of diacylhydrazine insecticides to the predatory bug Orius laevigatus: in vivo and modelling/docking experiments. Pest Management Science, 68 (12), 1586-1594.
  • Barea C., Pabon A., Galiano S., Perez-Silanes S., Gonzalez G., Deyssard C., Monge A., Deharo E, Aldana I. (2012). Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. Molecules, 17 (8), 9451-9461.
  • Barre A, Rougé P . Chapitre1. Structure moléculaire des allergènes de l’arachide et des fruits à coque, in  Allergies Alimentaires, Elsevier Masson SA, Paris (sous presse).
  • Bengochea P., Christiaens O., Amor F., Vinuela E., Rouge P., Medina P., Smagghe G. (2012). Ecdysteroid receptor docking suggests that dibenzoylhydrazine-based insecticides are devoid of any deleterious effect on the parasitic wasp Psyttalia concolor (Hym. Braconidae). Pest Management Science, 68 (7), 976-985.
  • Bertani S., Houel E., Jullian V, Bourdy G, Valentin A., Stien D., Deharo E. (2012). New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae). Experimental Parasitology, 130 (4), 341-347.
  • Borges J., Gironde C., Collin F., Grabowska A., Rouge P., Barre A. (2012). Beta-lactoglobulin from buffalo’s milk is responsible for anaphylactic shock without cross-reactivity to other mammalian milks. Allergy, 67 (96), 149-150.
  • Bouquet J., Rivaud M., Chevalley Séverine, Deharo E, Jullian V, Valentin A. (2012). Biological activities of nitidine, a potential antimalarial lead compound. Malaria Journal, 11.
  • Bourdy G., Jullian V., Deharo E., Auberger P., Robert, G. Utilisation de la Simalikalactone E comme agent anticancéreux. Fr. Demande2012,  FR 2970415 A1 2012 PCT Int. Appl. 2012, WO 2012095820 A1 20120719.
  • Cachet N., Ho-A-Kwie F., Rivaud M., Houëll E., Deharo E, Bourdy G, Jullian V. (2012). Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae). Phytochemistry Letters, 5 (1), 162-164.
  • Fabre N., Deharo E, Le H. L., Girardi C., Valentin A., Jullian V. (2012). LC-ESI-MS/MS analysis of Quassia amara leaves tea. Is antiplasmodial activity of the tea is due to quassinoids?. Planta Medica, 78 (11), 1262-1262.
  • Festa C., De Marino S., D’Auria M. V., Deharo E, Gonzalez G., Deyssard C., Petek Sylvain, Bifulco G., Zampella A. (2012). Gracilioethers E-J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris. Tetrahedron, 68 (49), 10157-10163.
  • Garavito G., Bertani S., Quiliano M., Valentin A., Aldana I., Deharo E. (2012). The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. Memorias do Instituto Oswaldo Cruz, 107 (6), 820-823.
  • Haddad M, Le Lamer A. C., Moreno y Banuls L., Carraz M, Vasquez P., Vaisberg A., Castillo D., Sauvain M, Rojas R., Kiss R. (2012). In vitro growth inhibitory effects of 13, 28-epoxyoleanane triterpene saponins in cancer cells. Planta Medica, 78 (11), 1184-1185.
  • Houël E., Rodrigues A., Jahn-Oyac A., Bessière J. M., Eparvier V., Deharo E, Stien D. (2012). In vitro antifungal activity of Otacanthus azureus (Linden) Ronse essential oil alone and in combination with azoles. Planta Medica, 78 (11), 1202-1202.
  • Houël, E., Stien, D., Bourdy G., Deharo, E. (2012) Quassinoids: anticancer and antimalarial activities. In Handbook of Natural Products. Springer Ed.
  • Iriart X, Lavergne RA, Fillaux J, Valentin A, Magnaval JF, Berry A, Cassaing S. Performances du spectromètre de masse VITEKMS (MALDI-TOF) pour l'identification des espèces fongiques isolées en routine au CHU de Toulouse. J. Mycol. med. 2012, 22: 277-8.
  • Lavergne R. A., Cassaing S., Nocera T., Pauwels C., Cointault O., Basse G., Lavayssiere L., Berry A., Kamar N., Lamant L., Iriart X., Linas M. D., Valentin A., Fillaux J., Paul C., Magnaval J. F. (2012). Simultaneous cutaneous infection due to Paecilomyces lilacinus and Alternaria in a heart transplant patient. Transplant Infectious Disease, 14 (6), E156-E
  • Le H. L., Jullian V, Bourdy G, Girardi C., Deharo E, Le Lamer A. C., Fabre N. (2012). Sensitivity enhancement in LC-ESI-MS method using mobile phase additives to quantify Simalikalactone E. Planta Medica, 78 (11), 1198-1198.
  • Mani L., Jullian V, Mourkazel B., Valentin A., Dubois J., Cresteil T., Folcher Eric, Hooper J. N. A., Erpenbeck D., Aalbersberg W., Debitus Cécile. (2012). New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888. Chemistry and Biodiversity, 9 (8), 1436-1451.
  • Nguyen HD., Phan TT., Carraz M., Brunsveld L. (2012) Estrogen receptor α/β-cofactor motif interactions; interplay of tyrosine 537/488 phosphorylation and LXXLL motifs. Mol. Biosyst. 2012, 8, 3134-3141.  IF = 3.4
  • Olounlade P. A., Azando E. V. B., Hounzangbe-Adote M. S., Ha T. B. T., Leroy E., Moulis C., Fabre N., Magnaval J. F., Hoste H., Valentin A. (2012). In vitro anthelmintic activity of the essential oils of Zanthoxylum zanthoxyloides and Newbouldia laevis against Strongyloides ratti. Parasitology Research, 110 (4), 1427-1433.
  • Rivaud M., Mendoza A., Sauvain M, Valentin A., Jullian V. (2012). Short synthesis and antimalarial activity of fagaronine. Bioorganic and Medicinal Chemistry, 20 (15), 4856-4861.
  • Robert G., Jullian V, Jacquel A., Ginet C., Dufies M., Torino S., Pottier A., Peyrade F., Tartare-Deckert S., Bourdy G, Deharo E, Auberger P. (2012). Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway. Oncotarget, 3 (12), 1688-1699.
  • Rojas-Duran R., Gonzalez-Aspajo G., Ruiz-Martel C., Bourdy G, Doroteo-Ortega V. H., Alban-Castillo J., Robert G., Auberger P., Deharo E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143 (3), 801-804.
  • Zotti M. J., Christiaens O., Rouge P., Grutzmacher A. D., Zimmer P. D., Smagghe G.  (2012). Sequencing and structural homology modeling of the ecdysone receptor in two chrysopids used in biological control of pest insects. Ecotoxicology, 21 (3), 906-918.



Vendredi 13 Novembre 2020 : Séminaire

6 novembre 2020 |  

Notre prochain séminaire Pharma-DEV se déroulera vendredi  13 novembre à 14h en visio par Zoom uniquement. Julia Mocquart, doctorante co-encadrée par...

Jeudi 8 octobre 2020 : Séminaire

25 septembre 2020 |  

Le prochain séminaire se tiendra le jeudi 8 octobre à 14h30 en présentiel et en visio. Nous aurons le plaisir d'écouter,...

Vendredi 25 septembre 2020 : Séminaire

17 septembre 2020 |  

Reprise des séminaires de l'UMR vendredi 25 septembre à 14h ! François Chassagne, nouvelle recrue de l'unité en tant que CR...

septembre 2020 : Recrutement

11 septembre 2020 |  

Bienvenue à Alice Gadea, nouvelle MCU au sein du service de Pharmacognosie-botanique-mycologie de la faculté de pharmacie de Toulouse, et qui...

Mercredi 8 juillet 2020 : Workshop sur les réseaux moléculaires

29 juin 2020 |  

Il s'agit de la 2ème partie, pratique cette fois, du séminaire de Sergio Ortiz (post-doc équipe PEPS) sur les réseaux moléculaires....

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