The main mission of PHARMADEV researchers is to contribute to improving the health of the populations of the least developed countries, thus working towards their development. Our approach mainly concerns parasitic pathologies (malaria and leishmaniasis), cancer, and more particularly hepatocellular carcinoma (HCC), which has a high prevalence in developing countries. The search for new therapeutic strategies against these diseases involves :
- The study of their etiology and pathogenesis
- The discovery of new bioactive molecules from plant biodiversity
- The study of redox deregulations involved in the maintenance or resolution of pathologies.
In addition, we wish to focus on plant-derived endophytic microorganisms as a renewable source of bioactive molecules and to better understand the chemical interactions between the fungal microbiome and its host plant.
In order to respond to these missions, and to encourage synergies between the members of the unit, our unit is structured in scientific axes. This organisation also allows chemists and biologists to meet on common themes. Our three thematic axes and the transversal axis aiming at promoting the valorisation of research projects are as follow:
- “Chemodiversity and biology of pathologies in the South” (CHIPS)
- “Chemical ecology of symbiotic organisms” (ECOS)
- ” Cellular pathology and redox deregulation” (PARADOX)
- “Development and valorisation” (DEEVA)
The 3 thematic axes interact as shown in the figure below: