The unit’s strategy is based on four groups at the interface of chemistry and biology, the common thread of which is the targeted pathology.
Chemistry provides molecules of different origins:
- Molecules of natural origin drawn from biodiversity, using an ethnopharmacological or chemotaxonomic approach.
- Bioactive synthetic molecules interacting with endogenous redox systems.
Biology includes two approaches:
- The first focused on general screening models, whole parasites and cancer cells. This approach allows the bioguiding of extractive chemistry and pharmacochemical modelling to identify biotoxic compounds for the pathogens or cancer cells studied.
- The second uses specific targets, such as transcription factors and nuclear receptors involved in monocyte/macrophage line activation pathways. This research axis results from upstream research on the molecular mechanisms of macrophage polarization and the consequences of this polarization in the evolution of the pathologies studied. Molecules able to polarize macrophages can constitue pharmacological strategies to orient towards a phenotype favourable to clinical improvement.